Alpha Keto Analogue
Description
FadvitaTM is a therapy for treatment of Chronic Kidney Disease(CKD) wherein patients are on conservative treatment especially when there is some residual renal function left in stage I, II and III of Chronic Kidney Disease(CKD).
FadvitaTM, is a combination of alpha ketoanalogues and essential amino acids given to patients with very low protein or a low protein diet to slower the progression of CKD.
Indication
FadvitaTM is indicated in prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency with limited protein in food of 40 g per day (for adults) and less; i.e. generally in patients with a Glomerular filtration rate (GFR) below 25 ml/min.
Contraindications
Hypercalcemia, disturbed amino acid metabolism. In case of hereditary phenylketonurie it has to be taken into account that this product has phenylalanine.
Precautions and Warnings
No experience has been made so far with the application in pregnancy and pediatrics. FadvitaTM need be taken during meals to allow proper absorption and metabolism into the corresponding amino acids. The serum calcium level should be monitored regularly. Adequate supply of calories should be ensured.
Undesirable effects
Hypercalcemia may develop. In this case, it is recommended to decrease vitamin D intake. If the hypercalcaemia persists, reduce the dose of FadvitaTM as well as any other source of calcium.
Drug Interactions
Simultaneous administration of medicinal products that contain calcium like acetolyte could trigger/worsen, a pathological increase in serum calcium level. As the uremic symptoms improve under the therapy of FadvitaTM tablets, the dose of aluminum hydroxide administered should be reduced likely. The patient should be monitored for reduced levels of serum phosphate.In order not to interfere with absorption, an appropriate interval should be observed between administration of FadvitaTM tablets and medicinal products which form poorly soluble compounds with calcium like tetracyclines, quinolones such as ciprofloxacin and norfloxacin, preparations that contain iron, fluoride and estramustin. An interval of at least 2 hours should be observed between the intake of FadvitaTM tablets and such medicinal products. If upon administration of FadvitaTM tablets leads to increased blood levels of calcium, the sensitivity to medicinal products which increase heart action (cardiac glycosides) and thus also the risk of cardiac arrhythmia is increased
Dosage
One tablet of FadvitaTM per 5kg/body weight/day during meals every day for entire duration as prescribed by consultant
Storage
Do not use FadvitaTM after expiry date Keep out of the reach of children Protect from moisture Do not store above 25°C
Benefits:
- FadvitaTM reduces uraemic symptoms which is largely due to accumulation of degradation products of the protein metabolism
- FadvitaTM peserves the residual renal function so slows down the progression of the chronic kidney disease
- FadvitaTM preserves the nutritional status, despite the marked reduction of the daily protein intake
- Improvement of metabolic complications due to renal insufficiency like proteinuria, disturbances in calcium-phosphate, carbohydrate and lipid metabolism
Presentation
| Each FadvitaTM tablet contains | ||
| Calcium 3-methy-2oxo-valerate | (α-ketoanalogue of isoleucine,calcium salt) | 67 mg |
| Calcium 4-methy-2oxo-valerate | (α-ketoanalogue of leucine,calcium salt) | 101 mg |
| Calcium-2-oxo-3-phenylpropionate | (α-ketoanalogue of phenylalaline,calcium salt) | 68 mg |
| Calcium-3-methyl-2-oxo-butyrate | (α-ketoanalogue of valine,calcium salt) | 86 mg |
| Calcium-DL-2-hydroxy-4(methylthio) butyrate | (α-hydroxyanalogue of methionine,calcium salt) | 59 mg |
| L-Lysine Acetate | USP | 105 mg |
| L-Threonine | USP | 53 mg |
| L-Tryptophan | USP | 23 mg |
| L-Histidine | USP | 38 mg |
| L-Tyrosine | USP | 30 mg |
| Total Nitrogen Content /Tablet | 36 mg | |
| Calcium Content/Tablet | 1.25 mmol=^ 0.05 gm |
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.