Sodium Bicarbonate
Auxalis® (Sodium Bicarbonate) is an alkali therapy to manage metabolic acidosis indicated in the treatment of metabolic acidosis which may occur in severe Renal Disorder, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Auxalis® (Sodium bicarbonate) acts as an acid neutralizer which helps to neutralize hydrogen ion concentration and raises blood and urinary pH.Auxalis® (Sodium bicarbonate) supplementation is recommended for Chronic Kidney Disorder patients whose bicarbonate lab levels are less than 22 mmol/L. Auxalis®, a base, helps to neutralize and decrease the blood acid levels, reverses the clinical manifestations of acidosis, increases the free bicarbonate ions in urine hence effectively raise the urinary pH.
Presentation
Blister pack of Auxalis® in one strip 10 tablets and 10 strips in a box
Composition
Each Auxalis® Tablet contains Sodium Bicarbonate I.P. 500 mg
Mode Of Action:
Sodium bicarbonate is a salt that breaks down in fluids, including blood and urine, to form sodium and bicarbonate. This breakdown buffers the blood and makes it less acidic. This ability to neutralize acid helps treat conditions related to high acidity in bodily fluids, such as indigestion, which is caused by too much acid in the stomach.
Indications
Metabolic acidosis Urinary Alkalinization Dyspepsia Acidosis
Contraindications
Sodium Bicarbonate is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis, metabolic and respiratory alkalosis; hypocalcemia in which alkalosis may produce tetany, hypertension, convulsions or CHF; when administration of sodium could be clinically detrimental.
Precautions
Sodium Bicarbonate should not be used if you have certain medical conditions. Before using this product, consult your doctor if you have: a certain breathing problem (pulmonary edema), congestive heart failure, severe kidney disease (e.g.,inability to make urine), severe liver disease (e.g., ascites, cirrhosis), high sodium levels, and swollen ankles/legs/feet due to retaining water (peripheral edema). If you have any of the following health problems, consult your doctor before using Sodium Bicarbonate:low calcium levels, high blood pressure, heart problems like irregular heartbeat and kidney disease. Because this medication contains salt (sodium), do not use if you are on a salt-restricted diet. During pregnancy, this medication should be used only when clearly needed. This medication may worsen high blood pressure during pregnancy (toxemia of pregnancy). Discuss the risks and benefits with your doctor. This medication may pass into breast milk. Consult doctor before breast-feeding.
Side Effects and Adverse Reactions
Some of the side effects although may occur rarely with Sodium Bicarbonate are nausea or vomiting, headache, muscle pain, swelling of feet, ankles or legs, decreased appetite, unusual tiredness, constipation, dry mouth or increased thirst or increased urination. Some of the common adverse reactions which may occur with Sodium Bicarbonate are Exacerbation of CHF, Rebound hyperacidity, milk-alkali syndrome, Hypernatremia, alkalosis, Extravasations with cellulitis, tissue necrosis, ulceration, venous irritation, tetany or edema.
Dosage
325- 2000mg orally for 1- 4 times a day for moderate metabolic acidosis. The cumulative dosage of Sodium Bicarbonate in certain conditions goes up to 16 grams per day.
Concomitant Therapy
Sodium Bicarbonate can decrease elimination of amphetamine, dextroamphetamine, ephedrine, flecainide, mecamylamine , methamphetamine, pseudoephedrine and quinidine, thus increasing their therapeutic effects. Sodium Bicarbonate can increase elimination of Chlorpropamide, lithium, methotrexate, salicylates and tetracyclines, thus decreasing their therapeutic effects.
Overdosage
Sodium Bicarbonate should be stopped in alkalosis, manage the patient according to the degree of alkalosis present. 0.9% sodium chloride injection intravenous may be given; potassium chloride also may be indicated if there is hypokalemia. Severe alkalosis may be accompanied by hyperirritability or tetany and these symptoms may be controlled by calcium gluconate. An acidifying agent such as ammonium chloride may also be indicated in severe alkalosis.
Storage
Store in a cool, dry place. Protect from light and moisture.
Benefits Of Auxalis®
Auxalis® may prevent dose overload in stomach which can improve GI tolerance in CKD patients
Auxalis® helps in delaying the progression of Chronic Kidney Disease.
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.